Sulfotransferase catalyzing sulfation of heterocyclic amines

Cytosolic sulfation of arylamines to form sulfamates is found to be mediate d by sulfotransferases of three gene families (SULT1 to 3). Among them, a S ULT3 form (ST3A1) showed a high selectivity for N-sulfation of N-substitute d aryl and alicyclic compounds. SULT1 (phenol) and SULT2 (hydroxysteroid) s ulfotransferases showed N-sulfating activities of carcinogenic heterocyclic amines. For N-hydroxyarylamine O-sulfation, SULT1 forms showed high activi ty. In rats, ST1C1 mediated the metabolic activation of N-hydroxyarylamines . However, the related form. (ST1C2) in humans showed the negligible activi ty. Instead, ST1A3 showed high metabolic activating abilities among human s ulfotransferases. (C) 1999 Published by Elsevier Science Ireland Ltd. All r ights reserved.