Analysis of tracheal sounds during forced exhalation in asthma patients and normal subjects - Bronchodilator response effect

Purpose: During the past 10 years, the acoustic analysis of breath sounds h as been used as a diagnostic tool in patients suffering from obstructive re spiratory diseases. Acoustic analysis might be able to monitor the response to bronchodilator therapy in a clinical setting. So far, few studies have been carried out in asthmatic patients. To assess the responses of a sampli ng of asthma patients to an inhaled bronchodilator (terbutaline) by means o f spectral analysis of the tracheal sound performed during forced expirator y maneuvers. Material and methods: Seventeen nonsmoking asthma patients (9 were male, 8 were female) who had been suffering from the disease for greater than or eq ual to 15 years were included in the study, as were 15 normal subjects (7 w ere male, 8 were female). The average age (+/- SD) was 56.5 +/- 15.2 years (FVC, 2.7 +/- 0.9 L [63.4%]; FEV1, 1.5 +/- 0.6 L [53.0%]). The tracheal sou nds were collected during three forced expiratory maneuvers with a sampling frequency of 5,000 Hz and were analyzed by applying a 16-parameter autoreg ressive model. Results: The centroid frequency decreased after the bronchodilator was give n at different flow segments between 1.2 and 0.4 L/s, with significant chan ges between 0.6 and 0.4 L/s, Conclusions: Patients with asthma showed changes in the spectral acoustic a nalysis frequencies after the administration of a bronchodilator drug (terb utaline) during forced expiratory maneuvers.