Neurogenic tumors of the mediastinum are among the most common mediastinal
tumors. They include nerve sheath, autonomic nervous system, and paragangli
onic tumors and malignant small cell tumor. Neurogenic tumors arise primari
ly in the paravertebral sulcus. They are most frequently identified as asym
ptomatic lesions on routine chest X-rays. The majority of symptoms can be r
elated either to compression of neural elements or other intrathoracic stru
ctures or to excess production of biogenic amines. Complete surgical excisi
on performed by a thoracotomy approach offers the best opportunity for cure
. In the case of tumors with extension into the spinal canal, a combined th
oracic and neurosurgical approach should be performed.