Objective. The stress throughout the fifth metatarsal was determined u
nder various loading conditions, in order to better understand the cau
ses of fractures to this bone. Design. A mathematical approach was tak
en, in which the stresses were analysed using the methods of beam theo
ry. Background. Finite element analysis has frequently been used to de
termine the stress in bones. Beam theory provides an easier method for
determining the force and moment resultant in any cross-section. The
distribution of stress throughout the cross-section can then be found
by solving certain partial differential equations defined on the cross
-sections. Methods. Cross-sections of the bone were obtained by slicin
g a mould, into which the bone was placed, at numerous intervals along
its length. Analytic expressions describing each cross-section were o
btained by fitting a Fourier series to a sequence of points along the
boundary. Results. The maximum stress found in the fifth metatarsal re
sulted from an oblique load, and had a magnitude less than would occur
in a subject during normal walking. Conclusions. Since the magnitude
of the stress is submaximal, this study lends theoretical support to t
he clinical observation that the diaphyseal fracture is indeed a stres
s fracture. Relevance Our analysis adds a biomechanical rationale to t
he pathomechanics of diaphyseal stress fractures of the fifth metatars
al. It suggests that inversion during repetitive activities may predis
pose the foot to fractures at a predictable location. (C) Elsevier Sci
ence Ltd.