Calcific uremic arteriolopathy in association with low turnover uremic bone disease

We report seven cases (out of 100 dialysis patients) at the University of K entucky who were diagnosed with calciphylaxis syndrome between 1993 and 199 8. Of note is the fact that five of these patients had bone biopsy-proven a dynamic renal bone disease, rather low intact PTH, and relatively low calci um-phosphorus product. This is in contrast to the previous view that calcip hylaxis is usually seen in patients with excessive parathyroid activity. Th e reemergence of calciphylaxis with renal bone disease is an intriguing fin ding and does not correspond to earlier reports associating calciphylaxis w ith hyperparathyroid bone disease. This report reviews the clinical, bioche mical, and bone histology findings of these patients (Table 1), and provide s a review of the literature.