Kidney involvement in a 17-year-old boy with eosinophilic fasciitis

Eosinophilic fasciitis (EF) is characterized by symmetrical scleroderma-lik e induration of skin over one or more distal extremities, peripheral eosino philia, absence of Raynaud phenomenon and visceral involvement and a favour able response to systemically administered corticosteroids. Like other scle roderma-like disorders EF is rarely described in children. We report renal involvement in a 17-year-old boy with EF, Urinalysis disclosed proteinuria. Prior to corticosteroid therapy renal biopsy was performed which revealed ischemic collapse of glomerular capillaries and atrophy of tubules of the c ortex. Electron-microscopic studies showed hyperplasia of the renin-produci ng epitheloid cells in the juxtaglomerular apparatus. Few other publication s have depicted renal involvement in EF of quite different character. In th ese cases renal biopsy and histological classification is warranted because of prognostic and therapeutic implications.