Maternal effect of Type 2 diabetes mellitus on insulin sensitivity and metabolic profile in healthy young Mexicans

The objective of this study was to identify the maternal effect of type 2 d iabetes mellitus (T2DM) on insulin sensitivity and metabolic profiles of yo ung healthy, Mexican people (n = 15). A cross-sectional study was performed in these subjects with a family history of T2DM in both first and second d egree relatives on the maternal side and 15 control subjects. The following tests were carried out: insulin tolerance test and metabolic profile. Syst olic blood pressure and serum uric acid were significantly higher in proban ds than controls. Insulin sensitivity was not different between either grou p studied (4.7 +/- 0.9 in probands vs 4.5 +/- 0.8 %/min in controls; p = 0. 52). In conclusion: family history of T2DM on the maternal side increased b oth systolic blood pressure and serum uric acid level in probands, without modification in their insulin sensitivity. Triglycerides concentration had a tendency to be higher in probands than controls. (C) 1999, Editrice Kurti s.