Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer

Multiple lines of evidence implicate steroid hormone and growth factor cros s-talk as a modulator of endocrine response in breast cancer and that aberr ations in growth factor signaling pathways are a common element in the endo crine resistant phenotype. Delineation of these relationships is thus an im portant diagnostic goal in cancer research, while the targeting of aberrant growth factor signaling holds the promise of improving therapeutic respons e rates.