Citation
Zh. Sui et al., Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones, EUR J MED C, 34(5), 1999, pp. 381-387
Citations number
28
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234
→ ACNP
Volume
34
Issue
5
Year of publication
1999
Pages
381 - 387
Database
ISI
SICI code
0223-5234(199905)34:5<381:SATIAO>2.0.ZU;2-3
Abstract
A series of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed an
d synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisome
rase II. Structure activity relationships of the compounds against each of
the enzymes are discussed. (C) Elsevier, Paris.