Effects of single and repeated stresses on the expression of mRNA for or alpha(1)-adrenoceptors in the rat hypothalamus and midbrain

Authors
Miyahara, S Komori, T Fujiwara, R Shizuya, K Yamamoto, M Ohmori, M Okazaki, Y
Citation
S. Miyahara et al., Effects of single and repeated stresses on the expression of mRNA for or alpha(1)-adrenoceptors in the rat hypothalamus and midbrain, EUR J PHARM, 379(1), 1999, pp. 111-114
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
379
Issue
1
Year of publication
1999
Pages
111 - 114
Database
ISI
SICI code
0014-2999(19990820)379:1<111:EOSARS>2.0.ZU;2-9
Abstract
We examined the effects of single or repeated stress on the expression of m RNA for alpha(1)-adrenoceptors in the rat hypothalamus and midbrain using t he reverse transcriptase-polymerase chain reaction (RT-PCR). Single stress significantly increased the mRNA. level for alpha(1)-adrenoceptors in the m idbrain, but had no effect on mRNA levels in the hypothalamus. Repeated str ess significantly decreased mRNA levels for alpha(1)-adrenoceptors in both regions. (C) 1999 Elsevier Science B.V. All rights reserved.