PREPARATION OF BETA-AMINO ALCOHOLS BY CARBON-CARBON BOND FORMATION USING SUBSTITUTED LITHIOMETHYLPYRROLIDINES

Authors
COLDHAM I HOLMAN S LANGANDERSON MS
Citation
I. Coldham et al., PREPARATION OF BETA-AMINO ALCOHOLS BY CARBON-CARBON BOND FORMATION USING SUBSTITUTED LITHIOMETHYLPYRROLIDINES, Journal of the Chemical Society. Perkin transactions. I, (10), 1997, pp. 1481-1485
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
10
Year of publication
1997
Pages
1481 - 1485
Database
ISI
SICI code
0300-922X(1997):10<1481:POBABC>2.0.ZU;2-6
Abstract
N-Thiomethylation or stannylmethylation of prolinol derivatives, follo wed by sulfur-lithium or tin-lithium exchange is used for the formatio n of alpha-amino-organolithiums. Condensation with aldehydes gives bet a-amino alcohols in good yield but modest diastereoselectivity.