V. Mirone et al., Our experience on the association of a new physical and medical therapy inpatients suffering from induratio penis plastica, EUR UROL, 36(4), 1999, pp. 327-330
Objectives: To check the efficiency of shock waves in the treatment of indu
ratio penis plastica. The Minilith SL1, successfully used in orthopedic or
salivary stones because of its lithotriptic power, can be used to break pla
ques in Peyronie's disease. Methods: A total of 130 patients affected with
Peyronie's disease were entered into a prospective trial. Patients with com
pletely calcified plaques as determined by ultrasound evaluation were exclu
ded. We divided the patients into three treatment groups: (A) shock waves a
lone in 21 patients; (B) a combination of shock waves and verapamil (perile
sional injection) in 36 patients, and (C)verapamil alone in 73 patients. Fi
rst, we treated all groups A and B patients 3 times, 20 min each time, with
a Minilith SL1, and then only the patients of the second group received a
complete cycle of twelve injections of verapamil (10 mg) every 2 weeks for
6 months. The group of 73 patients (group C) treated during the previous 2
years with a medical therapy (only injection of verapamil) was used as a co
ntrol group. Results: Ultrasound evaluation showed a reduction of plaque in
11/21 group A patients and 7/36 group B patients. The treatment was tolera
ted very well and only 11 petechiae in some patients were noticed after ESW
treatment. Conclusions: The therapeutic association of shock waves with ve
rapamil injection is an effective nonoperative treatment for the stabilizat
ion of Peyronie's disease.