The in vitro effects of new non-steroidal antiinflammatory compounds on antioxidant system of human erythrocytes

It has been reported by our group that some benzoxazolone and benzothiazolo ne derivatives showed significant antinociceptive and anti-inflammatory act ivity [DOGRUER et al. 1997]. It has been speculated that nonsteroidal anti-inflammatory drugs (NSAIDs) c an act as the free radical scavengers and possess antioxidant activity. It is also well documented that oxidative stress can play an important role in the side effects of many xenobiotics including NSAIDs. Therefore, in the p resent study, the effects of six of the above mentioned benzoxazolone and b enzothiazolone derivatives bearing 2-pyridylaminocarbonylmetyl moiety at th e position 3 (I) on the antioxidant system-related parameters of human eryt hrocytes have been investigated. Diclofenac and nimesulid were also tested in the same systems as the control, because they are commonly used as NSAID s. Our results showed that these compounds made significant changes in the ant ioxidant system of human erythrocyte. [GRAPHICS]