The effect of folic acid on the drug metabolizing liver function in man with viral hepatitis

The investigations were carried out on 31 patients (16 men and 15 women, at the age of 20-50) with viral hepatitis. The all patients were divided at t wo groups. The first group (12 man) received usual treatment (diet, corsil) , the second group (19 man) received in addition to the base treatment foli c acid (5 mg per day, 10 days). It was found, that at patients with viral h epatitis was decreased the activity of mono-oxygenase system of liver. So, period of semielimination (T1/2) of antipyrine (AP) was greater in 1,4 time , area under the pharmacokinetic curve - 1,5 time and clearance was below b y 39 % than in volunteers (29 man). On day of treatment only by corsil, the rate of elimination of AP and clearance were increased by 34 and 31 % (p < 0.05) respectively, T1/2 was decreased by 23 % (p < 0.05) and area under t he pharmacokinetic curve - 17 %. On 10 day of treatment by corsil with foli c acid (5 mg per day), the rate of elimination of AP and clearance was incr eased by 43 % (p < 0.05), area, under the pharmacokinetic curve and T 1/2 w ere decreased by 30 and 33 % (p < 0.05) respectively. The positive effect o f folic acid in treatment of hepatitis at restoration period may be cause p articipating its derivatives in de novo nucleotide synthesis.