Intracytoplasmic sperm injection (I): Outcome of 310 pregnancies

Objective: To evaluate the outcomes of 310 pregnancies after intracytoplasm atic sperm injection (ICSI) at one institution. Methods: Chart reviews. Results: The pregnancy rate per transfer was 27.2 %. The multiple pregnancy rate was 21 %. The overall pregnancy loss rate was 25.7 % (74 spontaneous abortions, 4 tubal pregnancies and 2 heterotopic pregnancies). Prenatal eva luation was performed in 34.1 % of cases. The only abnormalities were seen in patients with a positive family history and an abnormal karyotype in one parent. 37 % of the spontaneous abortions available for analysis showed ab normal karyotypes, a rate consistent with the literature. In eight couples in which the male partner had a chromosomal anomaly there were no differenc es in fertilization rates or pregnancy rates. The multiple pregnancies did not seem to be associated with an increased rate of complications of pregna ncy. Conclusion: These results are consistent with those in the literature.