Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP(38) content in the rat adrenals

Authors
Ginda, WJ Nussdorfer, GG Malendowicz, LK
Citation
Wj. Ginda et al., Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP(38) content in the rat adrenals, HORMONE MET, 31(8), 1999, pp. 483-485
Citations number
13
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
HORMONE AND METABOLIC RESEARCH
ISSN journal
00185043 → ACNP
Volume
31
Issue
8
Year of publication
1999
Pages
483 - 485
Database
ISI
SICI code
0018-5043(199908)31:8<483:EOBSSA>2.0.ZU;2-4
Abstract
Pituitary adenylate cyclase-activating polypeptide (PA-CAP) is a basic 38-a mino acid regulatory peptide contained in the adrenal gland and involved in the control of its secretory activity. Bilateral splanchnic-nerve section caused in the rat a significant decrease in PACAP(38) adrenal content and c oncentration, as measured by RIA. In contrast, chemical sympathectomy, obta ined by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important rol e in the control of rat adrenal function.