Association of angiotensin-converting enzyme gene polymorphism with lipid profiles in children and adolescents with insulin-dependent diabetes mellitus

We attempted to clarify the association between angiotensin-converting enzy me (ACE) gene polymorphism and the other predictive factors for macroangiop athy in children and adolescents with uncomplicated insulin-dependent diabe tes mellitus (IDDM), Sixty-three patients were divided into 3 groups accord ing to the ACE genotypes. The lipid profiles were evaluated according to AC E genotypes, The level of lipoprotein(a) (Lp(a)) in the It genotype was sig nificantly lower than that in groups with the D allele, Lp(a) significantly correlated with apo B/apo A-I (p < 0.001, r = 0.63) and atherogenic index (AI = (total cholesterol - high-density lipoprotein cholesterol)/high-densi ty lipoprotein cholesterol; p = 0.004, r = 0.36), We suggest that the D all ele may affect the level of Lp(a) and the other lipid profiles in IDDM.