Immunopathology of alphamethrin in bovine calves

Immunopathological effects of alphamethrin, a synthetic pyrethroid, was stu died in 6 crossbred male bovine calves. The results showed that the blastog enic activity of T- and beta- lymphocytes reduced 48 and 40%, respectively, in alphamethrin fed calves in comparison to controls. There was significan t decrease in BoCD(4)(+), (T- cytotoxic), brucella specific antibody titres and total Ig G and Ig M titres in alphamethrin fed calves. Alphamethrin wa s found to have immunosuppressive effect at a dose of 5 mg/kg bw which may lead to increased susceptibility to various diseases.