Growth kinetics of Salmonella abortus equi infection in C57BL/6 mice

Citation
Rj. Tirpude et al., Growth kinetics of Salmonella abortus equi infection in C57BL/6 mice, I J ANIM SC, 69(7), 1999, pp. 466-468
Citations number
8
Categorie Soggetti
Animal Sciences
Journal title
INDIAN JOURNAL OF ANIMAL SCIENCES
ISSN journal
03678318 → ACNP
Volume
69
Issue
7
Year of publication
1999
Pages
466 - 468
Database
ISI
SICI code
0367-8318(199907)69:7<466:GKOSAE>2.0.ZU;2-F
Abstract
Mouse protection test is the method of choice for evaluating the potency of a given vaccine where the bacterial challenge dose and route of administra tion play a crucial role. In this study therefore, bacterial growth kinetic s of Salmonella abortus equi was studied in susceptible inbred C57BL/6 mice in liver and spleen by different routes. Results indicate that the peak ba cterial growth was evident by intravenous route by day 5 post infection (PI ) in both liver (16.37 +/-2.65 x 10(6) CFU) and spleen (5.87 +/- 1.52 x 10( 6)). A sharp decline in bacterial growth: was detected after day 10 PI Subc utaneous route showed a lower bacterial growth kinetics whereas oral route indicated the lowest bacterial growth. However, the pattern of sustaining t he bacterial growth in terms of time schedule was consistent with the intra venous route.