Biochemical changes relevant to cardiovascular function in lead intoxicated calves

Effects of lead were evaluated oil some biochemical parameters related to c ardiovascular function in calves by giving lead acetate @ 5.0 mg (equivalen t to 2.73 mg of lead)/kg body weight till the appearance of clinical signs of toxicity in calves. Lead exposure increased levels of serum cholesterol and triglycerides in calves from day 28 onwards. Serum sodium and potassium levels did not change significantly but concentrations of calcium decrease d after lead exposure. Change in creatinine phosphokinase (CPK) level was m ost pronounced at the later stage of the experiment. These calves also reve aled increasing concentration of lead in blood. Our findings revealed that lead affects cardiovascular system of bovine.