S. Kishore et al., Cellular interaction in the generation of suppressor cells and mitogen induced proliferation of intestinal mucosal leukocytes of buffalo, I J ANIM SC, 69(5), 1999, pp. 281-283
Nonspecific suppressor cell and lymphoproliferative activity was induced in
gut associated lymphoid tissue (GALT), viz. intestinal intraepithelial leu
kocytes (IELs), lamina propria leukocytes (LPL) and peripheral blood leukoc
ytes (PBL). Depletion and reconstitution of adherent cells (macrophage/mono
cyte) revealed that these cells were indispensible in both the activities.
Autologous as well as allogenic were equally potent. Addition of 2 mercapto
ethanol (2 ME) to non-adherent cells could not substitute the macrophage re
quirement though 2 ME potentiated these responses in presence of adherent c
ells.