Uterine defense modulation for the treatment of repeat breeding due to infectious endometritis in bovines

Citation
Ps. Saini et al., Uterine defense modulation for the treatment of repeat breeding due to infectious endometritis in bovines, I J ANIM SC, 69(5), 1999, pp. 307-309
Citations number
15
Categorie Soggetti
Animal Sciences
Journal title
INDIAN JOURNAL OF ANIMAL SCIENCES
ISSN journal
03678318 → ACNP
Volume
69
Issue
5
Year of publication
1999
Pages
307 - 309
Database
ISI
SICI code
0367-8318(199905)69:5<307:UDMFTT>2.0.ZU;2-P
Abstract
The selected cows (n=54) were randomly assigned to one of the 4 treatment g roups to study the effect of immunomodulators on uterine defense mechanism (UDM) in repeat breeding bovines. The treatment was started during estrus ( day 0). Cows in group A (n=10) were given autologous plasma (50 ml IU daily for 3 days) in group B (n=8) levamisole (2.5 mg/sc) on days 0, 2, 6, 10, 1 4 and 18 of the estrous cycle, in group C (n=8) autologous plasma and levam isole, in group D (n=18) E.coli lipopolysaccharide (LPS, 100 mu g IU single dose), and group E (n=10) gentamicin (400 mg IU daily for 4 days). The ani mals were inseminated during estrus following treatment. In groups D, E, B, C and A, 14 (78%), 8 (80%), 4 (50%), 3 (37%) and 2 (20%) cows, respectivel y, conceived within 3 successive inseminations. It was concluded that intra uterine E. coli LPS infusion effectively improved stimulation of non-specif ic (cellular) immunity and elimination of endometritis.