Uterine defense modulation for the treatment of repeat breeding due to infectious endometritis in bovines

The selected cows (n=54) were randomly assigned to one of the 4 treatment g roups to study the effect of immunomodulators on uterine defense mechanism (UDM) in repeat breeding bovines. The treatment was started during estrus ( day 0). Cows in group A (n=10) were given autologous plasma (50 ml IU daily for 3 days) in group B (n=8) levamisole (2.5 mg/sc) on days 0, 2, 6, 10, 1 4 and 18 of the estrous cycle, in group C (n=8) autologous plasma and levam isole, in group D (n=18) E.coli lipopolysaccharide (LPS, 100 mu g IU single dose), and group E (n=10) gentamicin (400 mg IU daily for 4 days). The ani mals were inseminated during estrus following treatment. In groups D, E, B, C and A, 14 (78%), 8 (80%), 4 (50%), 3 (37%) and 2 (20%) cows, respectivel y, conceived within 3 successive inseminations. It was concluded that intra uterine E. coli LPS infusion effectively improved stimulation of non-specif ic (cellular) immunity and elimination of endometritis.