Anaphylactic response to parasite antigens: IgE and IgG1 independently induce death in Trichinella-infected mice

The response of animals infected with different Trichinella species (T. spi ralis, T: britovi, T: pseudospiralis) to antigens of different Trichinella species was evaluated in outbred mice (CD1) and inbred mice (BALB/c, C3H, S JL, C57BL/6), In mice deficient for IgE or IgG1, T.spiralis only was used. In homologous conditions (i.e., same Trichinella species for antigens and i nfectious agent) mortality was very high (up to 100% in SJL and C57BL/6). T he anaphylactic response in heterologous conditions was much lower and deat h was observed only in C57BL/6 and SJL mice. Experiments with deficient mic e have shown that both specific IgE and IgG1 independently induce a fatal a naphylactic response.