Computerized analysis of gray-value profiles in spongy and cortical bone -Clinical experience

RATIONALE AND OBJECTIVES. Osteoporosis is characterized by a loss of bone m ineral density and deterioration of structure. The authors present a struct ural parameter for the quantitative assessment of osteoporotic changes in v ertebral bone. METHODS. In 40 patients without or with known osteoporotic fractures, spong iosa and cortical bone mineral density was measured in lumbar vertebrae 1 t o 3 by quantitative CT. Additional axial high-resolution CT slices were obt ained for the structural analysis. In the spongiosa, the gray-value profile along a horizontal line in the CT slice was used, whereas in the cortical shell a profile was obtained from the cortical ridge. Both profiles were in tersected with a horizontal line of variable position, and the maximum numb er of intersections was determined. RESULTS. The maximum number of intersections is significantly higher in cas es with fractures (spongiosa 48.6, cortical shell 77.3) than in cases witho ut fractures (spongiosa 42.1, cortical shell 62.4). It also correlates with bone mineral density and age. CONCLUSIONS. The presented method shows significantly different numeric res ults for patients with and without osteoporotic fractures. The analysis is easy to perform and provides additional information on the bone structure t hat may be used in combination with bone mineral density measurements.