Dipeptides from methionine and S-methylcysteine as chiral ligands for asymmetric Michael reactions

Authors
Christoffers, J
Citation
J. Christoffers, Dipeptides from methionine and S-methylcysteine as chiral ligands for asymmetric Michael reactions, J PRAK CH C, 341(5), 1999, pp. 495-498
Citations number
19
Categorie Soggetti
Chemistry
Journal title
JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG
ISSN journal
09411216 → ACNP
Volume
341
Issue
5
Year of publication
1999
Pages
495 - 498
Database
ISI
SICI code
0941-1216(1999)341:5<495:DFMASA>2.0.ZU;2-5
Abstract
Dipeptides derived from methionine and S-methylcysteine 3a-d have been prep ared and screened as chiral ligands in combination with 13 metal salts 4a-m towards the catalysis of an asymmetric Michael reaction of a P-keto ester 1 with methyl vinyl ketone 2 resulting in an optimal ee of 18% achieved wit h FeCl3. 6H(2)O 4c as the metal salt.