Human bronchial artery blood flow after lung Tx with direct bronchial artery revascularization

The inaccuracy of measuring human bronchial artery blood flow has previousl y been considerable. En bloc double-lung transplantation with bronchial art ery revascularization (BAR) using a single conduit offers the unique opport unity of direct measurement of the total bronchial artery blood flow. In ei ght en bloc double-lung-transplanted patients with complete BAR, the basal blood flow was measured by using a 0.014-in. Doppler guide wire and arterio graphy. The average peak velocity in the conduit was 12-73 cm/s [+/-2.1 (SD ) cm/s], and the conduit diameter was 1.7-3.1 mm [+/-0.10 (SD) mm], giving individual basal flow values between 19 and 67 ml/min [+/-5 (SD) ml/min], o r 0.2-1.9% of estimated cardiac output. In three patients basal measurement s were followed by injection of nitroglycerin and verapamil into the condui t. This increased the bronchial artery flow to 121-262% of basal values (31 -89 ml/min). The measured values appear more physiologically plausible than previous bronchial artery blood flow measurements in humans.