Sequence specific interaction of the photoactive drug hypericin depends onthe structural arrangement and the stability of the structure containing its specific 5 ' AG3 ' target: A resonance Raman spectroscopy study

Authors
Kocisova, E Chinsky, L Miskovsky, P
Citation
E. Kocisova et al., Sequence specific interaction of the photoactive drug hypericin depends onthe structural arrangement and the stability of the structure containing its specific 5 ' AG3 ' target: A resonance Raman spectroscopy study, J BIO STRUC, 17(1), 1999, pp. 51-59
Citations number
29
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
ISSN journal
07391102 → ACNP
Volume
17
Issue
1
Year of publication
1999
Pages
51 - 59
Database
ISI
SICI code
0739-1102(199908)17:1<51:SSIOTP>2.0.ZU;2-W
Abstract
The resonance Raman spectra of three oligonucleotides with different length s containing a specific 5'AG3' target doubler for hypericin - a potent anti retroviral and anticancer photoactive agent, and their 1:1 and I:2(oligonuc leotide : hypericin) complexes are reported. It is shown that the structura l arrangement of the oligonucleotides, their structural stability and the l ocal structural arrangement around the 5'AG3' hypericin taro,er, are the fa ctors which determine the formation of a stable, specifically bounded DNA-h ypericin complexes.