Inheritance and genetic mapping of the Campus syndrome (CPS): A high-frequency tremor disease in pigs

A new progressive tremor disorder called Campus syndrome (CPS) was observed among the progeny of a normal boar of the Pietrain breed in Germany. Exten sive backcross experiments indicate that CPS is inherited as an autosomal d ominant trait, and the founder boar, Campus, is believed to be a gonadal mo saic. A linkage analysis of 57 animals mapped the CPS gene to a region on p orcine chromosome 7 flanked by the markers SW1418 and SW352, which is homol ogous to a part of human chromosome (HSA) 14, Human dominant distal myopath y type 1 (MPD1) has been mapped to the homologous region of HSA14, As the m yopathological findings in MDP1 show striking similarities to CPS, this por cine disorder may serve as an animal model for MPD1.