Ch. Kao et al., Evaluation of regional cerebral blood flow with Tc-99m-HMPAO in primary antiphospholipid antibody syndrome, J NUCL MED, 40(9), 1999, pp. 1446-1450
Citations number
24
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
In this study, Tc-99m-hexamethyl propyleneamine oxime (HMPAO) SPECT was use
d to evaluate the regional cerebral blood flow (rCBF) of the brain in patie
nts with primary antiphospholipid antibody syndrome (PAPS). Methods: Twenty
-two women who were PAPS patients, aged 28-60 y, with mild neuropsychiatric
manifestations and normal brain MRI findings were enrolled in this study.
Brain HMPAO SPECT was performed to detect brain abnormalities. Meanwhile, s
erum anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) were mea
sured. Results: HMPAO SPECT revealed hypoperfusion lesions in 16 of 22 (73%
) PAPS patients. Cerebral cortex and cerebellum were the most and the least
commonly involved areas, respectively. Eighteen of 22 (82%) and 14 of 22 (
64%) patients had positive ACA and positive LA, respectively. ACA and LA re
sults were related to HMPAO SPECT findings. Conclusion: HMPAO SPECT is a se
nsitive tool for detecting brain abnormalities in PAPS patients with only m
ild neuropsychiatric manifestations and normal brain MRI findings.