This study examined the relationship between costs of treating physical pro
blems and costs of treating depression, for 322 rural residents with depres
sion. Multiple regressions were used to control for sociodemographics, depr
ession severity, and physical and mental health comorbidities at baseline.
The results indicated a $1.42 (n = 322) reduction in the costs of treating
physical problems for a $1.00 increase in the costs of treating depression.
The reduction was $2.61 (p < 0.05) among those receiving depression treatm
ent (n = 125). These findings suggest a net savings from depression treatme
nt, in addition to other benefits such as improved symptoms and functioning
and increased productivity.