EFFICACY OF HYPERTHERMIA AND POLYUNSATURATED FATTY-ACIDS ON EXPERIMENTAL CARCINOMA

We investigated the efficacy of hyperthermia and gamma-linolenic acid on experimental carcinoma, This study focused on polyunsaturated fatty acids that are substrates for free radical reactions, Oleic acid, lin olenic acid, alpha-linolenic acid, or gamma-linolenic acid was injecte d into the arteries feeding AH109A carcinoma implanted into rat hind l imbs. Among these, gamma-linolenic acid had the greatest effect on tum or tissue lipid peroxidation and demonstrated an antitumor effect, Con sequently, gamma-linolenic acid injection into the feeding artery of a tumor was performed immediately prior to hyperthermia. This combinati on therapy induced a high level of lipid peroxidation in tumor tissue and a significant antitumor effect, Hyperthermia combined with gamma-l inolenic acid produces free radical reactions by increasing the radica l reaction substrate and may be an effective anticancer modality.