Computed tomographic findings of ceroid lipofuscinosis in a dog

A two-year and seven-month-old, castrated male border collie was presented for a two-month history of progressive neurological signs including blindne ss, ataxia, dementia, and partial seizures. A complete blood count, serum b iochemical profile, urinalysis, thoracic radiographs, and cerebrospinal flu id analysis were within reference ranges. Computed tomography (CT) of the b rain showed dilatation of the ventricles and atrophy of the cerebral cortex . A central nervous system (CNS) storage disease was suspected, and the dog was euthanized due to a poor prognosis. Light and electron microscopic exa mination revealed neuronal degeneration with pigment accumulation in neuron s of the CNS, in ganglia of the peripheral nervous system, and in several n on-nervous tissues. Ceroid lipofuscinosis was diagnosed based on the micros copic and ultrastructural lesions detected. This is the second report of CT findings in a canine clinical patient with ceroid lipofuscinosis.