Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

Authors
Habermann, J Ley, SV Smits, R
Citation
J. Habermann et al., Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents, J CHEM S P1, (17), 1999, pp. 2421-2423
Citations number
37
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
17
Year of publication
1999
Pages
2421 - 2423
Database
ISI
SICI code
0300-922X(1999):17<2421:TSOAAO>2.0.ZU;2-4
Abstract
An efficient combinatorial route to substituted 3-phenylbenzofurans, is ach ieved by the bromination of acetophenones to alpha-bromoacetophenones by po lymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1,5,7-triazabicyclo [4.4.0]dec-5-ene (TBD-P) and cyclodehydration of the resulting alpha-phenox yacetophenones using Amberlyst 15, affords pure products without the need f or any chromatographic purification step.