Synthesis and antiviral activity of prostaglandin-J(1) methyl ester

Authors
Roberts, SM Santoro, MG Guyot, T
Citation
Sm. Roberts et al., Synthesis and antiviral activity of prostaglandin-J(1) methyl ester, J CHEM S P1, (17), 1999, pp. 2437-2438
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
0300922X → ACNP
Issue
17
Year of publication
1999
Pages
2437 - 2438
Database
ISI
SICI code
0300-922X(1999):17<2437:SAAAOP>2.0.ZU;2-A
Abstract
A prostaglandin-F(1)alpha methyl ester derivative (12) possessing three dif ferent protecting groups on the hydroxy units was prepared so as to allow s elective removal of the group attached to the 11-OH group. Compound (12) wa s converted into prostaglandin-J(1) methyl ester (16) in two steps (77% ove rall yield). Prostaglandin-J(1) methyl ester showed potent activity against Sendai virus.