Clinical efficacy of micronized purified flavonoid fraction: An overview

Flavonoids are widely used for the treatment of chronic venous insufficienc y (CVI). In clinical trials, micronized purified flavonoid fraction (MPFF, 450 mg diosmin plus 50 mg hesperidin, Daflon 500 mg) has demonstrated its a ctivity in CVI by improving venous tone and vein elasticity assessed by ple thysmography. Randomized, double-blind, placebo-controlled clinical studies have shown an improvement in signs and symptoms related to CVI and a decre ase in leg circumferences at the levels of the ankle and calf. The effect o f MPFF on microcirculatory parameters suspected of participating in the pat hophysiological process of venous ulceration has been investigated in patie nts. These include hemorheological parameters and transcutaneous oxygen ten sion measurements, which were shown to improve after treatment with MPFF, F inally, a randomized double-blind, placebo-controlled clinical study has sh own that MPFF treatment for 2 months, in addition to standard compression t herapy, accelerates leg ulcer healing in patients with ulcers less than or equal to 10 cm.