Erigeron breviscapus prevents defective endothelium-dependent relaxation in diabetic rat aorta

Citation
Bh. Zhu et al., Erigeron breviscapus prevents defective endothelium-dependent relaxation in diabetic rat aorta, LIFE SCI, 65(15), 1999, pp. 1553-1559
Citations number
21
Categorie Soggetti
Biochemistry & Biophysics
Journal title
LIFE SCIENCES
ISSN journal
00243205 → ACNP
Volume
65
Issue
15
Year of publication
1999
Pages
1553 - 1559
Database
ISI
SICI code
0024-3205(19990903)65:15<1553:EBPDER>2.0.ZU;2-W
Abstract
We examined the endothelium-dependent relaxation response to acetylcholine (Ach) in streptozotocin-induced diabetic rat aorta at the stages of 2- and 6-wks' duration in vitro, and compared with another two groups which were t reated with dietary supplement of 0.1% Aminoquanidine (AG) and 0.5% Erigero n breviscapus(EB) from 1-week of diabetes induction. At the stage of 2-wks' duration of diabetes, relaxation responses to lower concentrations of Ach in 0.3uM phenylepherine-precontracted aortas were diminished significantly (P<0.05) compared with age-matched control, but the maximal relaxation of A ch remained unchanged. At the stage of 6-wks' duration, diabetes caused an approximately 60% (P<0.001) deficit in maximum relaxation, and this was sig nificantly (P<0.001) prevented in AG and EB treated groups. There was an ap proximately 40% enhancement in the maximum contractile response to phenylep herine with diabetes (P<0.05), which was unaffected significantly by AG and EB treatments. The data suggest that the defective endothelium-dependent r elaxation in diabetic rat aorta occurred as early as 2-wks' duration of dia betes, and the treatments of AG and EB could protect vascular endothelium a lthough the deficits in vascular smooth muscle contractile responses were n ot protected.