Potential carcinogenicity of the synthetic 1,3,6-triazine (6-azapyrimidine) nucleic acid analogues determined by DC polarography - II. Nucleosides of6-azauracil

The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleos ides with 6-azauracil as the nucleoside base in the strictly anhydrous solu tions was studied in the absence and presence of alpha-lipoic acid. The val ues of the half-wave potentials E1/2 and the parameter of potential carcino genicity tg a were compared for six nucleosides of 6-azauracil and two nucl eosides of 4-thio-6-azauracil. The current value of the first diffuse polar ographic wave or a new diffuse polarographic wave belonging to the nucleosi de-alpha-lipoic acid complex increased with the increase of the alpha-lipoi c acid concentration for the all compounds only marginally. Although this d iffuse current increase was linear and dependent on the alpha-lipoic acid c oncentration in anhydrous solutions, the determined index tg alpha values r anged between 0.027 and 0.114. This is an indication of a very low potentia l carcinogenicity of the all nucleoside analogues investigated.