Globus pallidus deep brain stimulation for generalized dystonia: Clinical and PET investigation

Authors
Kumar, R Dagher, A Hutchison, WD Lang, AE Lozano, AM
Citation
R. Kumar et al., Globus pallidus deep brain stimulation for generalized dystonia: Clinical and PET investigation, NEUROLOGY, 53(4), 1999, pp. 871-874
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
53
Issue
4
Year of publication
1999
Pages
871 - 874
Database
ISI
SICI code
0028-3878(19990911)53:4<871:GPDBSF>2.0.ZU;2-6
Abstract
Bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in a patient with severe idiopathic generalized dystonia resulted in immediate i mprovement of all aspects of dystonia. During joystick movement, GPi DBS re duced PET activation bilaterally in the primary motor, lateral premotor, su pplementary motor, anterior cingulate, and prefrontal areas and ipsilateral ly in the lentiform nucleus. Altering basal ganglia function with GPi DBS r everses the overactivity of certain motor cortical areas present in dystoni a.