HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar

Citation
E. Valdez et al., HLA characterization in adult asymptomatic cyst passers of Entamoeba histolytica/E. dispar, PARASIT RES, 85(10), 1999, pp. 833-836
Citations number
18
Categorie Soggetti
Microbiology
Journal title
PARASITOLOGY RESEARCH
ISSN journal
09320113 → ACNP
Volume
85
Issue
10
Year of publication
1999
Pages
833 - 836
Database
ISI
SICI code
0932-0113(199910)85:10<833:HCIAAC>2.0.ZU;2-Z
Abstract
The present work aimed at studying: the possible association of HLA antigen s with Entamoeba histolytica/E. dispar asymptomatic infection in a Mexican mestizo population. A case-control design was selected for evaluation of th e role of genetic markers in parasite infection. For this purpose the HLA-A , HLA-B, and HLA-DR profiles of a population of asymptomatic E. histolytica /E. dispar adult cyst passers (cases) and a corresponding nonparasitized ad ult group (controls) followed for 12 months were identified. Entamoeba spec ies were identified through zymodeme patterns and/or amplification of speci es-specific DNA sequences. A healthy, nonparasitized group of individuals w as included as a control. Our results show that apparently, no specific HLA marker is associated with the asymptomatic cyst passers' condition. These findings have to be added to previous results in which, in contrast to a de monstrated association between HLA-DR3 and amebic liver abscess in Mexican mestizo adults and infants, no significant association with amebic rectocol itis was found.