Effect of wood creosote and loperamide on propulsive motility of mouse colon and small intestine

To elucidate a mechanism of the antidiarrheal activity of wood creosote, it s effect on the propulsive motility of mouse colon and small intestine was studied using a charcoal meal test and a colonic bead expulsion test. The e ffect was compared with that of loperamide. At an ordinary therapeutic dose , wood creosote inhibited the propulsive motility of colon, but not of smal l intestine, On the other hand, loperamide inhibited the propulsive motilit y of small intestine, but not of colon. The results indicate that at least a part of the antidiarrheal activity of wood creosote and loperamide is att ributable to their anti-kinetic effect predominantly on colon of the former and predominantly on small intestine of the latter.