Dk. Miller et al., Chronic cadmium exposure attenuates conditioned place preference produced by cocaine and other drugs, PHARM BIO B, 64(1), 1999, pp. 15-20
Adult male rats were exposed ad lib for 40 days to 100 ppm dietary cadmium
chloride (group cadmium) or an identical diet with no added cadmium (group
control). Conditioned place preference (CPP) was conducted in a two-chamber
apparatus in which all drugs were paired with the least-preferred side as
determined by a pretest. In Experiment 1, animals received 0, 2.5, or 5 mg/
kg cocaine HCl (IP) for 4 days and vehicle only for 4 days. Control animals
showed a place preference for the drug side at 2.5 and 5 mg/kg, while the
cadmium-exposed animals showed a preference at 5 mg/kg only. In Experiment
2, animals received 0, 5, or 10 mg/kg of the D-1/D-2 dopamine receptor agon
ist apomorphine HCl (SC) for 4 days and vehicle only for 4 days. Control an
imals showed a place preference at 5 and 10 mg/kg, while metal-exposed anim
als showed a preference at 10 mg/kg only. To determine the possible effects
of alterations of learning mechanisms by cadmium, a conditioned place aver
sion (CPA) procedure was employed for Experiment 3. Animals received 0, 10,
or 40 mg/kg lithium chloride (IP) for 4 days or vehicle only for 4 days. C
ontrol animals showed a significant place aversion at 40 mg/kg, while cadmi
um-exposed animals did not. These findings are discussed within a framework
of possible metal-induced disturbance of neurochemical function and/or ass
ociative processing. (C) 1999 Elsevier Science Inc.