We analyze the prospects for observing CPT violation using neutral-meson P-
0-<(P-0)over bar> systems. Before one can claim a measurement of CPT violat
ion, one must be able to rule out the possibility that its result is due to
simpler new-physics effects. In particular, one must be able to separate t
he CPT-violating quantities from parameters violating the Delta P=Delta Q r
ule of semileptonic decays, and from new-physics contributions to the produ
ction mechanism of the neutral mesons. One can isolate CPT violation using
the semileptonic decays of single, tagged neutral mesons; unfortunately, th
is situation cannot be implemented at the Y(4S). For P-0<(P-0)over bar> pai
rs produced in a correlated parity-odd state we show that, by combining the
di-lepton with the single-lepton decays, it is in principle possible to ex
tract unambiguously one CPT-violating parameter. Finally, we develop the fo
rmalism necessary for describing new-physics effects in the production mech
anism; this includes both cascade decays and violations of the rule of asso
ciated production. [S0556-2821(99)04617-2].