The homeostasis of inner-ear fluids is essential for the functions of
hearing and equilibrium. Inner-ear disorders, such as Meniere's diseas
e, are affected by inner-ear pressure. The displacement of the human t
ympanic membrane can be studied by means of the MMS-10 Tympanic Displa
cement Analyser (Marchbanks Measurement Systems Ltd., UK) and is thoug
ht to be a measure for perilymphatic pressure variations. This measure
ment was performed in 18 patients with Meniere's disease (20 affected
ears) at regular intervals, in order to investigate possible pressure
variations in relation to the following symptoms: hearing loss, vertig
o, tinnitus and pressure sensation. Symptoms changed independently; ch
anges in symptoms were not significantly related to changes in perilym
phatic pressure, as measured by means of the MMS-10 analyser.