Eye-head coordination abnormalities and regional cerebral blood flow in Alzheimer's disease

1. Three patients with Alzheimer's disease (AD) and three healthy controls (HC) were examined for eye-head coordination. Regional cerebral blood flow (rCBF) was measured in AD patients. 2. Eye-head coordination was analyzed using a Vision analyzer, and magnetic sensors. The authors measured the rCBF with I-123-IMP, and Tc-99m-ECD SPEC T. 3. AD reduced gaze accuracy and head movements, and prolonged the latency o f saccade as compared to HC. AD patients had a tendency to focus on the tar get by using eye movements only. 4. AD reduced the rCBF in the inferior parietal past and the visual area, r elative to the motor area. Damage of these areas may have caused the eye-he ad coordination disorders in the AD patients.