Quantification of the formation of free radicals in macrophage systems

A mechanism is suggested for the zymosan stimulated, luminol dependent chem iluminescence of macrophage system both in the absence and in the presence of free radical inhibitor. Based on the mechanism and relevant data of elem entary rate constants computer simulation has been performed in order to de scribe the free radical formation and consumption, the kinetics of the chem iluminescence signal as well as the consumption of the inhibitor and lumino l molecules in the course of the overall process.