Ischemic cerebral vascular events in young subjects: a prospective study in 296 patients aged 16 to 45 years.

From 1990 to 1997, June, 296 patients (156 males and 140 females), aged 16 to 45 years, admitted in the Neurology Department of the University Hospita l of Nancy (F) for ischemic stroke, were prospectively evaluated according to a standardized analysis of anamnestic and clinical data, angiography (90 p. 100 of cases), TEE (78 p. 100), hemostasis. Women were younger (mean ag e = 34.82 y) than men (36.87; y; p = 0003), with a peak in the 4(th) decade . Clinical event was a TIA in 14.2 p. 100, a stroke in 51.7 p. 100; it conc erned the anterior circulation in 64.5 p. 100, posterior circulation in 25 p. 100, multiple territories in 10.5 p. 100. History of TIA, cervical-crani al pain or Horner syndrome suggestive of dissection, pregnancy or post-part um were found respectively in 60 (20.3 p. 100), 34 (11.1 p. 100) and 13 (9. 3 p. 100) cases. Risk factors concerned 87.2 p. 100 of patients, mainly smo king (55.1 p. 100), oral contraceptive (53 p. 100), hyperlipemia (35 p. 100 ), and were more frequent in case of atheroma and lacunar stroke (p < 0.000 0). Etiology, according to TOAST classification, was: atheroma (8.4 p. 100) , cardioembolism (8.7 p. 100), small-artery disease (7.1 p. 100), dissectio n (15.5 p. 100), other determined causes (11.1 p. 100), multiple causes (5. 7 p. 100), undetermined cause (34.8 p. 100). Septal pathology was found 34 times. Patients whose stroke remained unexplained were younger (33.7 y vs 3 7.7 p = 0.002), had less risk factors (p < 0.0000), had more TIA (p = 0.005 ), more often in the carotid territory (p = 0.008), had a better prognosis (p = 0.01), and showed more often emboli at angiography (p = 0.001). During a mean follow-up of 33 months (median = 19), PI reccurent strokes occurred and 6 patients died. 134 (46 p. 100) patients had no sequelae, 101 (34.7 p . 100) minor disability 42 (14.4 p. 100) major sequelae. These results, com pared to the main studies of the literature, suggest the interest of common definition criteria and classification of etiologies. In practice, hierarc hisation of investigations may be proposed, and vascular risk factors shoul d be tracked in young patients. In patients whose stroke remains unexplaine d, further studies, as atrial vulnerability, are needed.