In vivo estrogenic activity of branched and linear alkylphenols in rainbowtrout (Oncorhynchus mykiss)

Citation
Sn. Pedersen et al., In vivo estrogenic activity of branched and linear alkylphenols in rainbowtrout (Oncorhynchus mykiss), SCI TOTAL E, 233(1-3), 1999, pp. 89-96
Citations number
29
Categorie Soggetti
Environment/Ecology
Journal title
SCIENCE OF THE TOTAL ENVIRONMENT
ISSN journal
00489697 → ACNP
Volume
233
Issue
1-3
Year of publication
1999
Pages
89 - 96
Database
ISI
SICI code
0048-9697(19990815)233:1-3<89:IVEAOB>2.0.ZU;2-W
Abstract
The in vivo estrogenic activity of the two branched alkylphenols, tert-octy lphenol and technical nonylphenol, and the two linear isoforms, n-octylphen ol and n-nonylphenol, was compared. The compounds were administered to juve nile rainbow trout (Oncorhynchus mykiss) by either intraperitoneal injectio n or water exposure and their estrogenic potential was evaluated by ELISA m easurements of induced plasma vitellogenin. Intraperitoneal injections (50 mg/kg) of the two branched alkylphenols resulted in a significant vitelloge nic response after 12 days whereas no significant induction was seen with t he two linear isomers. Water exposure for 9 days to a nominal concentration of 150 mu g/l of the alkylphenols elicited the same response pattern as se en for the injection experiment. Furthermore, in the present vitellogenin a ssay tert-octylphenol was giving a higher estrogenic response compared to t echnical nonylphenol using either of the two exposure routes. (C) 1999 Else vier Science B.V. All rights reserved.