The synthesis of (E) and (Z)-combretastatins A-4 and a phenanthrene from Combretum caffrum

Authors
Lawrence, NJ Ghani, FA Hepworth, LA Hadfield, JA McGown, AT Pritchard, RG
Citation
Nj. Lawrence et al., The synthesis of (E) and (Z)-combretastatins A-4 and a phenanthrene from Combretum caffrum, SYNTHESIS-S, (9), 1999, pp. 1656-1660
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
9
Year of publication
1999
Pages
1656 - 1660
Database
ISI
SICI code
0039-7881(199909):9<1656:TSO(A(>2.0.ZU;2-7
Abstract
The synthesis of the trans stilbene E-combretastatin A-4 has been achieved via a Horner-Wittig reaction of (3,4,5-tri-methoxybenzyl)diphenylphosphine oxide. The anticancer drug Z-combretastatin A-4 was prepared by the hydrobo ration/protonation of a diaryl-alkyne.