Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors

Authors
Johnson, MG Bronson, DD Gillespie, JE Gifford-Moore, DS Kalter, K Lynch, MP McCowan, JR Redick, CC Sall, DJ Smith, GF Foglesong, RJ
Citation
Mg. Johnson et al., Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors, TETRAHEDRON, 55(39), 1999, pp. 11641-11652
Citations number
24
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
55
Issue
39
Year of publication
1999
Pages
11641 - 11652
Database
ISI
SICI code
0040-4020(19990924)55:39<11641:SPCATT>2.0.ZU;2-S
Abstract
A solid phase chemistry approach utilizing Mitsunobu chemistry, amine funct ionalization. and parallel purification was used to produce a diverse libra ry of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies. (C) 19 99 Published by Elsevier Science Ltd. All rights reserved.