N- vs O-alkylation in 2(1H)-quinolinone derivatives

Authors
Guo, ZX Cammidge, AN McKillop, A Horwell, DC
Citation
Zx. Guo et al., N- vs O-alkylation in 2(1H)-quinolinone derivatives, TETRAHEDR L, 40(38), 1999, pp. 6999-7002
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
38
Year of publication
1999
Pages
6999 - 7002
Database
ISI
SICI code
0040-4039(19990917)40:38<6999:NVOI2D>2.0.ZU;2-N
Abstract
N- vs O-alkylation reactions of 8-benzyloxy-2(1H)-quinolinone have been inv estigated using both classical and phase transfer conditions. The influence of reaction solvents/conditions was found to have a dramatic effect on sel ectivity, with opposite trends to that observed for 2-pyridone alkylation. (C) 1999 Elsevier Science Ltd. All rights reserved.